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NSAID renal adverse effect — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and Drug SafetyNSAID renal adverse effectGPhC CRA

An older patient taking ramipril and furosemide starts regular ibuprofen for knee pain. The GP asks what safety issue should be checked soon after starting. What monitoring is required?

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Correct answer: C — Renal function and electrolytes monitoring

NSAIDs can reduce renal perfusion, and the combination with an ACE inhibitor and diuretic increases acute kidney injury risk. Renal function and electrolytes should be monitored and the need for NSAID therapy reviewed. Hydration and sick-day advice may be relevant. INR and lithium monitoring are not routine unless those medicines are used.

Reference: BNF; NICE CKS