skip to main content

SGLT2 inhibitor sick day rules — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateEndocrine TherapeuticsSGLT2 inhibitor sick day rulesGPhC CRA

A patient taking dapagliflozin for type 2 diabetes is going abroad. They ask what to do if they develop vomiting and cannot maintain fluid intake. They also take metformin and ramipril. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Temporarily stop dapagliflozin during significant acute illness and seek advice

SGLT2 inhibitors can increase the risk of euglycaemic diabetic ketoacidosis, particularly during acute illness, dehydration or reduced intake. Patients should receive sick-day counselling and know when to seek medical help. Dose escalation during illness would increase risk.

Reference: BNF; MHRA Drug Safety Update