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Simvastatin liver symptoms — GPhC CRA MCQ

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HardRenal and Hepatic ImpairmentSimvastatin liver symptomsGPhC CRA

A patient taking simvastatin reports new dark urine, pale stools and marked fatigue. He has also noticed yellowing of his eyes. He asks whether to continue the tablets. What is the most appropriate action?

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Correct answer: A — Advise urgent medical assessment and withhold pending review

Jaundice symptoms require urgent medical assessment and may indicate significant liver disease or drug-induced liver injury. The patient should not simply continue without review. Statins can rarely be associated with hepatic adverse effects, and other causes also need evaluation. Grapefruit juice can increase simvastatin exposure and is not a management strategy.

Reference: BNF; MHRA Drug Safety Update