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Valproate pregnancy prevention — GPhC CRA MCQ

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ModerateCNS TherapeuticsValproate pregnancy preventionGPhC CRA

A 28-year-old woman taking sodium valproate for epilepsy asks whether she can stop contraception because she is planning pregnancy. She has no specialist appointment booked. She is currently seizure-free. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Advise urgent specialist review before pregnancy planning changes

Valproate is associated with serious teratogenic and neurodevelopmental risks. Pregnancy planning in patients taking valproate requires specialist review and risk minimisation measures. Abrupt discontinuation may cause seizures, while folic acid does not remove valproate-related risk.

Reference: MHRA Drug Safety Update; BNF