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H. pylori eradication interaction — GPhC CRA MCQ

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ModerateGastrointestinal TherapeuticsH. pylori eradication interactionGPhC CRA

A patient taking warfarin is prescribed clarithromycin, amoxicillin and omeprazole for H. pylori eradication. Their INR was stable last week. They ask whether any extra check is needed. What is the most important interaction to flag?

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Correct answer: B — Clarithromycin can increase anticoagulant effect and bleeding risk

Clarithromycin can interact with warfarin and increase bleeding risk, and infection or antibiotic therapy may also affect INR control. Anticoagulation monitoring advice should be arranged. The other options do not represent the key clinically important issue.

Reference: BNF