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Methotrexate pack selection — GPhC CRA MCQ

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HardDispensing and SupplyMethotrexate pack selectionGPhC CRA

A prescription requests methotrexate 2.5 mg tablets, take four tablets once weekly. The pharmacy also stocks 10 mg tablets. A dispenser suggests supplying fewer 10 mg tablets for convenience. What is the legal classification/requirement?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Supply the 2.5 mg strength unless the prescriber confirms otherwise

Methotrexate tablet strength confusion is a recognised cause of serious dosing errors. Supplying the prescribed 2.5 mg strength supports safer use unless a prescriber intentionally requests otherwise. Mixing strengths increases risk. The weekly schedule must be reinforced clearly.

Reference: BNF; MHRA Drug Safety Update