skip to main content

Statin muscle symptoms — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

EasyAdverse Drug Reactions and Drug SafetyStatin muscle symptomsGPhC CRA

A patient taking atorvastatin reports new severe muscle pain, weakness and dark urine after starting treatment for a chest infection. He is worried but has not contacted a doctor. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Refer urgently for assessment of possible rhabdomyolysis

Severe muscle symptoms with dark urine may indicate rhabdomyolysis, a rare but serious statin adverse effect. Urgent assessment, including creatine kinase and renal function, may be needed. Recent infection treatment may involve interacting medicines, increasing suspicion. Exercise and grapefruit juice could worsen risk.

Reference: BNF; MHRA Drug Safety Update