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SSRI and NSAID bleeding — GPhC CRA MCQ

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ModerateDrug InteractionsSSRI and NSAID bleedingGPhC CRA

A patient taking fluoxetine asks to buy ibuprofen for dysmenorrhoea. She has a previous history of gastritis and takes no gastroprotection. What is the most important interaction to flag?

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Correct answer: B — The combination can increase gastrointestinal bleeding risk

SSRIs can increase bleeding risk, and NSAIDs add gastrointestinal bleeding risk, especially in a patient with previous gastritis. The pharmacist should consider safer analgesia, gastroprotection needs or referral depending on severity. The interaction is clinically relevant even for short courses in higher-risk patients. It does not relate to reduced analgesic activity.

Reference: BNF