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PPI and clopidogrel — GPhC CRA MCQ

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ModerateGastrointestinal TherapeuticsPPI and clopidogrelGPhC CRA

A patient taking clopidogrel after a TIA is prescribed omeprazole 20mg daily for dyspepsia. The GP asks the pharmacy whether the PPI choice matters. The patient has no GI bleeding history. What is the most important interaction to flag?

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Correct answer: B — Omeprazole may reduce clopidogrel activation

Omeprazole can inhibit CYP2C19 and reduce formation of clopidogrel's active metabolite. An alternative PPI such as lansoprazole may be preferred if acid suppression is required. The other statements do not describe the relevant interaction.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-38