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NSAID gastroprotection — GPhC CRA MCQ

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ModerateGastrointestinal TherapeuticsNSAID gastroprotectionGPhC CRA

A 76-year-old patient is prescribed naproxen for osteoarthritis pain. They have a previous peptic ulcer and take aspirin 75mg daily. The prescription contains no gastroprotection. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Add a proton pump inhibitor after prescriber agreement

Older age, previous ulcer and concomitant aspirin increase NSAID-related GI bleeding risk. A PPI is commonly used for gastroprotection when NSAID therapy is necessary. Steroids, higher NSAID doses and duplicate NSAID exposure can increase harm.

Reference: BNF; NICE CKS