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Gabapentin renal dosing — GPhC CRA MCQ

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EasyRenal and Hepatic ImpairmentGabapentin renal dosingGPhC CRA

A 79-year-old with neuropathic pain is prescribed gabapentin 300 mg three times daily. His latest eGFR is 28 mL/min/1.73 m² and he reports recent falls and daytime sleepiness. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Query the dose because renal impairment increases toxicity risk

Gabapentin is renally eliminated and accumulation can cause sedation, dizziness and falls. The dose often needs adjustment in renal impairment, so the pharmacist should query the prescription or seek prescriber review. Pregabalin also requires renal dose consideration. Alcohol would worsen sedation and falls risk.

Reference: BNF