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Tramadol and SSRI interaction — GPhC CRA MCQ

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ModerateCNS TherapeuticsTramadol and SSRI interactionGPhC CRA

A patient taking sertraline 100mg daily is prescribed tramadol 50mg up to four times daily for back pain. They ask if there is anything important to know before starting it. They have no epilepsy history. What is the most important interaction to flag?

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Correct answer: E — The combination increases serotonin syndrome and seizure risk

Tramadol has serotonergic activity and can lower seizure threshold. Combined use with an SSRI increases the risk of serotonin syndrome and seizures. The prescription should be queried or monitored closely according to clinical context.

Reference: BNF