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SSRI and tramadol — GPhC CRA MCQ

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EasyDrug InteractionsSSRI and tramadolGPhC CRA

A patient taking sertraline 100 mg daily is prescribed tramadol for acute back pain. She has a history of epilepsy in childhood and asks about safety. What is the most important interaction to flag?

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Correct answer: D — The combination can increase serotonin toxicity and seizure risk

Tramadol has serotonergic activity and can lower seizure threshold. Combining it with an SSRI such as sertraline increases risk of serotonin syndrome and seizures, particularly in susceptible patients. The pharmacist should query the prescription and consider safer analgesic options. Constipation and dependence risks are not removed by sertraline.

Reference: BNF