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Heart failure beta-blocker initiation — GPhC CRA MCQ

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HardCardiovascular TherapeuticsHeart failure beta-blocker initiationGPhC CRA

A 69-year-old with stable HFrEF is to start Cardicor. Pulse is 82 beats/min, blood pressure 128/76 mmHg and ECG shows sinus rhythm without atrioventricular block. Which initiation schedule is licensed?

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Reveal the answer and explanation

Correct answer: C1.25 mg once daily for 1 week, then 2.5 mg once daily if tolerated

The Cardicor SmPC requires a gradual titration phase in stable chronic heart failure. Treatment starts with bisoprolol 1.25 mg once daily for one week and, if tolerated, increases to 2.5 mg once daily for a further week before subsequent staged increases. Heart rate, blood pressure and symptoms of worsening heart failure require close monitoring during titration.

Reference: Cardicor 1.25 mg film-coated tablets SmPC: https://www.medicines.org.uk/emc/product/5521/smpc