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Domperidone QT risk — GPhC CRA MCQ

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EasyGastrointestinal TherapeuticsDomperidone QT riskGPhC CRA

A prescription for domperidone 10mg three times daily is received for a 79-year-old patient with nausea. They also take amiodarone and have a history of arrhythmia. The course is written for 10 days. What is the most appropriate action?

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Correct answer: B — Query due to cardiac and QT prolongation risk

Domperidone is associated with QT prolongation and serious cardiac adverse effects, particularly in older people and those with interacting QT-prolonging medicines. Amiodarone adds to this risk, so the prescription should be queried. Increasing exposure or adding macrolides would worsen safety concerns.

Reference: BNF; MHRA Drug Safety Update