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DOAC and NSAID — GPhC CRA MCQ

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EasyDrug InteractionsDOAC and NSAIDGPhC CRA

A patient taking rivaroxaban for previous pulmonary embolism asks to buy naproxen for shoulder pain. She has no history of ulcer disease but bruises easily. What is the most important interaction to flag?

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Correct answer: B — Naproxen can increase bleeding risk with rivaroxaban

NSAIDs increase gastrointestinal and other bleeding risks when combined with anticoagulants such as rivaroxaban. The patient should be counselled and offered a safer analgesic approach or referred if pain requires anti-inflammatory treatment. Bruising may suggest increased bleeding tendency and warrants caution. The key issue is additive bleeding risk.

Reference: BNF