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Uncomplicated lower UTI — GPhC CRA MCQ

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ModerateInfectionsUncomplicated lower UTIGPhC CRA

A 31-year-old woman presents with dysuria and frequency for two days. She is not pregnant, has no fever or flank pain, and her eGFR is 68 mL/min/1.73 m². A GP asks which antibiotic is most appropriate first line. What is the most appropriate alternative?

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Correct answer: E — Nitrofurantoin modified-release 100 mg twice daily for 3 days

For non-pregnant women with uncomplicated lower UTI, nitrofurantoin is commonly used first line when renal function is adequate. The absence of fever or flank pain makes pyelonephritis less likely. Fluoroquinolones are avoided for routine uncomplicated UTI because of safety concerns and antimicrobial stewardship. Amoxicillin is unsuitable empirically where resistance is a concern.

Reference: NICE CKS; BNF