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Modified-release opioid crushing — GPhC CRA MCQ

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HardCNS TherapeuticsModified-release opioid crushingGPhC CRA

A patient collects oxycodone modified-release tablets and asks if they can crush them because they dislike swallowing tablets. They also have immediate-release oxycodone liquid for breakthrough pain. No swallowing assessment has been done. What would you advise the patient?

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Correct answer: E — Do not crush; contact the prescriber for a suitable formulation

Crushing modified-release opioid tablets can destroy the release mechanism and cause dose dumping. The prescriber should be contacted to consider an appropriate alternative formulation. Taking both opioid formulations routinely can increase overdose risk.

Reference: BNF; SmPC