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Sacubitril valsartan washout — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsSacubitril valsartan washoutGPhC CRA

A discharge letter asks the GP to change ramipril to sacubitril valsartan for heart failure. The patient took ramipril this morning. The GP asks the pharmacy whether the switch can be made today. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — ACE inhibitor overlap increases angioedema risk

Sacubitril valsartan must not be started too soon after an ACE inhibitor because of increased angioedema risk. A washout period is required when switching from an ACE inhibitor. The other options describe unrelated adverse effects or interactions.

Reference: BNF; SmPC