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Lithium NSAID interaction — GPhC CRA MCQ

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EasyCNS TherapeuticsLithium NSAID interactionGPhC CRA

A patient taking lithium asks to buy ibuprofen for dental pain. Their last lithium level was within range. They are otherwise well and have a dental appointment tomorrow. What is the most important interaction to flag?

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Correct answer: C — Ibuprofen can increase lithium concentration and toxicity risk

NSAIDs can reduce lithium clearance and increase serum lithium concentrations. The patient should avoid self-starting ibuprofen and seek advice on safer analgesia such as paracetamol if suitable. Lithium toxicity can be serious and may present with gastrointestinal symptoms, tremor, confusion or ataxia.

Reference: BNF