GORD in pregnancy — GPhC CRA MCQ
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Correct answer: D — Do not supply pseudoephedrine; recommend a non-sympathomimetic approach and alert the clinical team
Linezolid is a reversible, non-selective MAOI. It can markedly potentiate the pressor response to sympathomimetics such as pseudoephedrine, a particular concern in poorly controlled hypertension. Dose separation does not remove enzyme inhibition, and delayed monitoring misses the acute risk. A reduced OTC dose is not an adequate safeguard. The pharmacist should avoid the sympathomimetic, offer a suitable non-sympathomimetic measure if appropriate and communicate with the treating team; an OTC antibiotic cannot replace linezolid.
Reference: Linezolid 600 mg tablets SmPC. https://www.medicines.org.uk/emc/product/10239/smpc