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MAOI and sympathomimetic — GPhC CRA MCQ

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ModerateCNS TherapeuticsMAOI and sympathomimeticGPhC CRA

A patient taking phenelzine for depression asks to buy pseudoephedrine tablets for nasal congestion. Their BP today is 146/88 mmHg. What is the most important interaction to flag?

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Correct answer: D — Risk of hypertensive crisis with sympathomimetic decongestants

MAOIs can interact dangerously with sympathomimetic medicines such as pseudoephedrine, causing severe hypertension. The pharmacist should avoid supply and recommend safer alternatives such as saline measures where appropriate. The BP reading adds concern but the interaction is significant regardless. The other options do not reflect the mechanism or clinical risk.

Reference: BNF