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Tetracycline and isotretinoin — GPhC CRA MCQ

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ModerateDrug InteractionsTetracycline and isotretinoinGPhC CRA

A patient taking isotretinoin for acne is prescribed doxycycline by an out-of-hours clinician for a chest infection. They ask if it is safe. What is the most important interaction to flag?

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Correct answer: B — Risk of intracranial hypertension with isotretinoin and tetracyclines

Concomitant isotretinoin and tetracyclines can increase the risk of benign intracranial hypertension. The prescription should be queried and an alternative antibiotic considered. The patient should be advised to seek urgent help for severe headache, visual disturbance or vomiting. Isotretinoin teratogenic precautions remain essential.

Reference: BNF