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Nitrate and PDE5 inhibitor — GPhC CRA MCQ

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EasyCardiovascular TherapeuticsNitrate and PDE5 inhibitorGPhC CRA

A patient using isosorbide mononitrate modified-release for angina asks whether sildenafil bought online is safe to use. They have stable exertional angina and carry GTN spray. What is the most important interaction to flag?

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Correct answer: B — Severe hypotension can occur with nitrates and sildenafil

Nitrates and phosphodiesterase type 5 inhibitors can cause profound hypotension when used together. This interaction is clinically important even when angina is stable. The patient should be advised not to use sildenafil with nitrate therapy and to seek prescriber review for erectile dysfunction options. The other options do not describe the key risk.

Reference: BNF