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Statin myopathy — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetyStatin myopathyGPhC CRA

A patient taking atorvastatin 80 mg reports new severe muscle pain and dark urine after starting clarithromycin. What is the most appropriate action?

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Correct answer: A — Refer urgently for assessment of possible rhabdomyolysis

Severe muscle pain with dark urine suggests possible rhabdomyolysis, especially with a statin and interacting macrolide. The patient needs urgent clinical assessment, including creatine kinase and renal function. Continuing the statin without review could worsen harm. Dark urine in this context is a red flag.

Reference: BNF; MHRA Drug Safety Update