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Serotonin syndrome risk — GPhC CRA MCQ

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ModerateCNS TherapeuticsSerotonin syndrome riskGPhC CRA

A patient taking sertraline 100 mg daily is prescribed tramadol for acute back pain. They ask if the combination is safe. What is the most important interaction to flag?

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Correct answer: E — Increased risk of serotonin toxicity and seizures

Tramadol has serotonergic properties and can increase the risk of serotonin syndrome when combined with SSRIs. It also lowers seizure threshold, which is clinically relevant. The prescriber should consider alternative analgesia where appropriate. The patient should be counselled about symptoms such as agitation, tremor, sweating and diarrhoea if the combination is used.

Reference: BNF