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PPI administration — GPhC CRA MCQ

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EasyGastrointestinal TherapeuticsPPI administrationGPhC CRA

A patient starts omeprazole 20 mg once daily for reflux. They have been taking it after their evening meal and still wake with symptoms. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Take omeprazole before food, usually before breakfast

PPIs are usually taken before food, commonly before breakfast, to optimise proton pump inhibition. Capsules should be swallowed according to formulation instructions and not chewed unless an appropriate dispersible product is prescribed. Daily treatment may be needed for a trial period depending on indication. Iron does not improve PPI effect and can complicate administration schedules.

Reference: BNF; NICE CKS