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SSRI and NSAID bleeding — GPhC CRA MCQ

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ModerateDrug InteractionsSSRI and NSAID bleedingGPhC CRA

A patient taking fluoxetine 20 mg daily asks to buy naproxen for period pain. They have a past gastric ulcer. What is the most important interaction to flag?

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Correct answer: E — Fluoxetine and naproxen increase gastrointestinal bleeding risk

SSRIs can increase bleeding risk, and NSAIDs further increase gastrointestinal bleeding risk. A previous ulcer makes this clinically significant. The pharmacist should advise a safer analgesic option or prescriber review, and consider gastroprotection if NSAID use is necessary. The other options do not reflect the interaction.

Reference: BNF