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Pancreatin administration — GPhC CRA MCQ

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HardGastrointestinal TherapeuticsPancreatin administrationGPhC CRA

A 46 kg postoperative adult with no additional hepatotoxicity risk is prescribed paracetamol 10 mg/mL IV every six hours. They receive no other paracetamol. Which per-dose volume and resulting maximum daily dose match the SmPC?

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Correct answer: C — 69 mL per dose, giving a maximum of 2.76 g in 24 hours

For weight over 33 kg to 50 kg, the IV dose is 15 mg/kg, equivalent to 1.5 mL/kg of a 10 mg/mL solution. Thus 46 × 1.5 = 69 mL, containing 690 mg. Four six-hourly doses provide 2,760 mg, which also equals the weight-based maximum of 60 mg/kg/day and remains below the absolute 3 g cap. The fixed 1 g/100 mL adult regimen applies above 50 kg; using the upper weight-band volume rather than the actual weight risks overdose.

Reference: Paracetamol 10 mg/mL solution for infusion SmPC. https://www.medicines.org.uk/emc/product/15148/smpc