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Sildenafil and GTN — GPhC CRA MCQ

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EasyDrug InteractionsSildenafil and GTNGPhC CRA

A patient with angina using GTN spray requests sildenafil after seeing an online advert. They used GTN yesterday for chest pain on exertion. What is the most important interaction to flag?

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Correct answer: D — Severe hypotension can occur if sildenafil is used with nitrates

Nitrates and sildenafil can have additive vasodilatory effects causing severe hypotension, syncope or myocardial ischaemia. The patient should not use sildenafil with nitrate therapy and should seek prescriber advice. Recent GTN use also raises concern about active angina control. The other options are not clinically relevant.

Reference: BNF