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Amiodarone and warfarin — GPhC CRA MCQ

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ModerateDrug InteractionsAmiodarone and warfarinGPhC CRA

A patient stable on warfarin starts amiodarone after cardiology review. Their next INR appointment is in six weeks. What monitoring is required?

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Correct answer: D — Arrange closer INR monitoring because amiodarone can increase anticoagulation

Amiodarone can increase the anticoagulant effect of warfarin and the interaction may develop over time. Closer INR monitoring and possible warfarin dose adjustment are needed. Amiodarone also has its own thyroid, liver and pulmonary monitoring requirements. Waiting six weeks without anticoagulation review may be unsafe.

Reference: BNF