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Antiviral renal dosing — GPhC CRA MCQ

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HardInfectionsAntiviral renal dosingGPhC CRA

A frail 82-year-old patient with shingles is prescribed aciclovir 800 mg five times daily. Their eGFR is 24 mL/min/1.73 m². What is the most appropriate alternative?

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Correct answer: A — Query the dose because renal adjustment may be needed

Aciclovir is renally cleared and dose adjustment is required in renal impairment to reduce toxicity risk. Older, frail patients are particularly vulnerable to confusion and renal adverse effects. The prescriber should be contacted to confirm an appropriate regimen. Hydration is generally important unless clinically contraindicated.

Reference: BNF