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Clopidogrel and omeprazole — GPhC CRA MCQ

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ModerateDrug InteractionsClopidogrel and omeprazoleGPhC CRA

A patient taking clopidogrel after stroke buys omeprazole for reflux symptoms. They have no red-flag symptoms. What is the most important interaction to flag?

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Correct answer: B — Omeprazole can reduce clopidogrel activation and should be avoided if possible

Omeprazole inhibits CYP2C19 and can reduce activation of clopidogrel. A different acid-suppressing option with less interaction potential may be more suitable depending on symptoms and guidance. Stopping clopidogrel would be unsafe without prescriber advice. The patient should be referred if alarm symptoms are present.

Reference: BNF