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Hypertension resistant therapy — GPhC CRA MCQ

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HardCardiovascular TherapeuticsHypertension resistant therapyGPhC CRA

A 63-year-old patient takes ramipril 10 mg daily, amlodipine 10 mg daily and indapamide 2.5 mg daily. Home BP remains around 154/90 mmHg. Recent potassium is 4.2 mmol/L and eGFR is 64 mL/min/1.73 m². What is the most appropriate alternative?

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Correct answer: EDiscuss adding low-dose spironolactone with monitoring

For resistant hypertension, low-dose spironolactone may be considered when potassium is suitable and renal function allows. Monitoring of renal function and electrolytes is essential. Potassium supplementation would increase hyperkalaemia risk. The other options do not represent evidence-based escalation of antihypertensive treatment.

Reference: BNF; NICE CKS