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Digoxin toxicity — GPhC CRA MCQ

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HardCardiovascular TherapeuticsDigoxin toxicityGPhC CRA

A digoxin concentration is taken 2 hours after the morning dose and is unexpectedly high, but the patient is asymptomatic. What is the best interpretation step?

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Correct answer: C — Repeat the sample at least 6 hours post-dose before interpretation

Digoxin distributes slowly from plasma into tissues, so an early post-dose sample can appear misleadingly high. Concentrations should usually be sampled at least 6 hours, preferably 8 to 12 hours, after a dose and interpreted with symptoms, ECG, renal function and electrolytes.

Reference: BNF: digoxin: https://bnf.nice.org.uk/drugs/digoxin/