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Lamotrigine rash — GPhC CRA MCQ

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HardCNS TherapeuticsLamotrigine rashGPhC CRA

A patient started lamotrigine three weeks ago for epilepsy. They contact the pharmacy about a spreading rash with fever and mouth soreness. They have taken no new OTC medicines. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Advise urgent medical assessment and withhold further doses pending review

Lamotrigine can rarely cause serious skin reactions, especially early in treatment. Rash with fever or mucosal symptoms requires urgent medical assessment. Continuing or increasing the dose could be dangerous. Symptomatic OTC treatment alone is not appropriate.

Reference: BNF