skip to main content

DPP-4 inhibitor pancreatitis — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

HardAdverse Drug Reactions and Drug SafetyDPP-4 inhibitor pancreatitisGPhC CRA

A patient taking sitagliptin reports severe persistent upper abdominal pain radiating to the back with vomiting. They ask whether to continue the tablets. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Refer urgently for assessment of possible pancreatitis

Severe persistent abdominal pain radiating to the back with vomiting is concerning for pancreatitis. DPP-4 inhibitors have been associated with pancreatitis, and urgent medical assessment is needed. Continuing treatment without assessment may delay care. Antacids or loperamide do not address the red-flag presentation.

Reference: BNF; MHRA Drug Safety Update