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Clozapine infection symptoms — GPhC CRA MCQ

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HardCNS TherapeuticsClozapine infection symptomsGPhC CRA

A patient taking clozapine phones asking for advice about a sore throat, fever and mouth ulcers. Their next blood test is not due for ten days. What monitoring is required?

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Correct answer: BArrange urgent same-day assessment and blood count advice

Clozapine can cause agranulocytosis and neutropenia, and symptoms such as fever, sore throat or mouth ulcers require urgent assessment. The clozapine monitoring service or clinical team should be contacted promptly. Waiting for routine monitoring could delay recognition of a serious adverse effect. Permanent discontinuation should be managed by the specialist team unless emergency advice requires withholding.

Reference: BNF