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Lithium and NSAID — GPhC CRA MCQ

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ModerateDrug InteractionsLithium and NSAIDGPhC CRA

A patient taking lithium asks to buy ibuprofen for a sprained ankle. They have normal renal function but have had lithium toxicity in the past. What is the most important interaction to flag?

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Correct answer: E — NSAIDs can increase lithium concentrations and toxicity risk

NSAIDs can reduce renal lithium clearance and increase lithium levels, leading to toxicity. Previous toxicity increases concern. Safer analgesia and prescriber advice should be considered. The patient should know toxicity symptoms such as tremor, vomiting, diarrhoea, confusion and ataxia.

Reference: BNF