skip to main content

Methotrexate counselling — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

EasyPatient Counselling and Pharmaceutical CareMethotrexate counsellingGPhC CRA

A patient starts methotrexate for rheumatoid arthritis and collects folic acid. They ask which symptoms should prompt urgent advice. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: A — Report sore throat, fever, mouth ulcers, bruising or breathlessness promptly

Methotrexate can cause serious blood, liver and lung toxicity. Symptoms such as sore throat, fever, mouth ulcers, unexplained bruising or breathlessness require prompt medical advice. The patient must understand weekly dosing and monitoring. Trimethoprim should be avoided unless the prescriber has assessed the interaction.

Reference: BNF; SPS