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Digoxin and verapamil — GPhC CRA MCQ

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ModerateDrug InteractionsDigoxin and verapamilGPhC CRA

A patient taking digoxin for AF is newly prescribed verapamil modified-release for rate control. They report occasional nausea already. What is the most important interaction to flag?

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Correct answer: E — Verapamil can increase digoxin concentration and toxicity risk

Verapamil can increase digoxin levels and both medicines can slow AV conduction. Existing nausea could be an early sign of digoxin adverse effects. The prescription should be reviewed and monitoring considered. Pulse, symptoms, renal function and digoxin level may be relevant depending on clinical context.

Reference: BNF