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Apixaban dose assessment — GPhC CRA MCQ

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HardCardiovascular TherapeuticsApixaban dose assessmentGPhC CRA

A patient taking apixaban has a life-threatening gastrointestinal bleed requiring reversal in hospital. Which reversal agent is recommended by NICE for this indication?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Andexanet alfa administered under the approved hospital protocol

NICE recommends andexanet alfa as an option for reversing apixaban or rivaroxaban in adults with life-threatening or uncontrolled gastrointestinal bleeding. Idarucizumab reverses dabigatran, vitamin K reverses warfarin over time, and protamine does not specifically reverse apixaban.

Reference: NICE TA697: andexanet alfa for reversing apixaban or rivaroxaban: https://www.nice.org.uk/guidance/ta697/chapter/1-Recommendations