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Clozapine constipation safety — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetyClozapine constipation safetyGPhC CRA

A patient taking clozapine asks for a laxative after no bowel movement for five days, abdominal bloating and reduced appetite. What is the most appropriate action?

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Correct answer: A — Refer urgently because clozapine-related gastrointestinal hypomotility can be serious

Clozapine can cause severe constipation and gastrointestinal hypomotility, which can be life-threatening. Five days without bowel movement with bloating and reduced appetite requires urgent assessment. Loperamide and codeine would worsen bowel hypomotility. Prevention and early treatment of constipation are essential in clozapine care.

Reference: MHRA Drug Safety Update; BNF