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Carbimazole agranulocytosis — GPhC CRA MCQ

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ModerateEndocrine TherapeuticsCarbimazole agranulocytosisGPhC CRA

A patient taking carbimazole 20 mg daily for Graves’ disease asks for throat lozenges. They have a sore throat, mouth ulcers and fever. What is the most appropriate action?

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Correct answer: D — Advise urgent medical assessment and blood count before further doses

Carbimazole can rarely cause agranulocytosis, presenting with sore throat, fever or mouth ulcers. The patient needs urgent assessment and a full blood count, with specialist advice on whether to stop treatment. Symptomatic OTC treatment alone could delay recognition of a serious adverse effect. The pharmacist should not independently switch thyroid therapy.

Reference: BNF