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Methotrexate weekly dosing — GPhC CRA MCQ

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EasyMusculoskeletal TherapeuticsMethotrexate weekly dosingGPhC CRA

A patient newly prescribed methotrexate 10 mg tablets for rheumatoid arthritis presents a prescription written as 'take as directed'. They say the consultant told them it was weekly but they are unsure which day. What is the most appropriate action?

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Correct answer: ADo not dispense until the weekly dose and day are clarified

Methotrexate for rheumatoid arthritis is a high-risk medicine taken once weekly, and daily dosing errors can be fatal. The prescription must state clear dose instructions before supply. The patient should receive counselling on weekly dosing, folic acid, toxicity symptoms and monitoring. Unclear directions are unsafe.

Reference: BNF; MEP