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Valproate pregnancy prevention — GPhC CRA MCQ

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HardCNS TherapeuticsValproate pregnancy preventionGPhC CRA

A 24-year-old patient taking sodium valproate for epilepsy asks for an emergency supply because they have run out while away from home. The record shows they are enrolled in specialist review and have no alternative plan. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Assess emergency supply, reinforce pregnancy prevention advice and contact the usual care team

Valproate is teratogenic and subject to strict pregnancy-prevention and risk-reduction requirements, but abrupt interruption in epilepsy can be dangerous. The pharmacist should manage continuity safely, reinforce required counselling and documentation, and liaise with the usual care team. Refusal without considering seizure risk is not person-centred. Pharmacists should not switch antiepileptic therapy without prescriber involvement.

Reference: MHRA Drug Safety Update; BNF