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Fluconazole interaction — GPhC CRA MCQ

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ModerateInfectionsFluconazole interactionGPhC CRA

A patient taking simvastatin 40 mg daily is prescribed fluconazole 150 mg as a single dose for candidiasis. They ask if any medicine needs pausing. What is the most important interaction to flag?

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Correct answer: B — Fluconazole can increase simvastatin exposure and myopathy risk

Azole antifungals can inhibit metabolism of some statins and increase myopathy or rhabdomyolysis risk. Even with a single dose, the interaction should be considered and managed according to BNF and prescriber advice. The patient should report muscle pain, weakness or dark urine. The other options do not describe the key risk.

Reference: BNF