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Lithium monitoring — GPhC CRA MCQ

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HardCNS TherapeuticsLithium monitoringGPhC CRA

A patient stable on lithium modified-release 400 mg twice daily receives a new indapamide prescription. What should happen before routine co-administration?

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Correct answer: BContact the prescriber and plan lithium and renal monitoring

Thiazide and thiazide-like diuretics can reduce lithium clearance and precipitate toxicity. The combination should be reviewed before supply; if clinically necessary, lithium dose and concentration need close monitoring alongside renal function and toxicity counselling.

Reference: BNF: lithium carbonate: https://bnf.nice.org.uk/drugs/lithium-carbonate/