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Hepatic impairment and statins — GPhC CRA MCQ

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ModerateRenal and Hepatic ImpairmentHepatic impairment and statinsGPhC CRA

A 62-year-old man with fatty liver disease starts atorvastatin for primary prevention. Baseline ALT is mildly raised but less than three times the upper limit of normal. What monitoring is required?

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Correct answer: A — Liver function should be checked according to statin monitoring guidance

Statins can be used in many patients with stable liver disease, but liver function should be checked at baseline and during early treatment according to guidance. Mild transaminase elevation alone does not necessarily preclude use. The patient should report unexplained muscle symptoms. The other tests do not monitor statin hepatic safety.

Reference: BNF