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Pioglitazone heart failure risk — GPhC CRA MCQ

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ModerateEndocrine TherapeuticsPioglitazone heart failure riskGPhC CRA

A 70-year-old man with type 2 diabetes and a history of heart failure presents with a new prescription for pioglitazone. He currently has ankle swelling and breathlessness on exertion. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Contact the prescriber because pioglitazone can worsen heart failure

Pioglitazone can cause fluid retention and is contraindicated or inappropriate in heart failure depending on clinical context. Current oedema and breathlessness increase concern. The prescriber should review the choice before supply. Stopping diuretics would risk worsening fluid overload.

Reference: BNF; NICE CKS